![]() ![]() Mepolizumab use has been associated with herpes zoster infection Herpes Zoster Herpes zoster is infection that results when varicella-zoster virus reactivates from its latent state in a posterior dorsal root ganglion. Allergic hypersensitivity reactions have been reported with mepolizumab. Anaphylaxis may occur after any dose of dupilumab, benralizumab, omalizumab, or reslizumab even if previous doses have been well tolerated. Inappropriate immune reactions include those that are. read more or allergic hypersensitivity reactions Overview of Allergic and Atopic Disorders Allergic (including atopic) and other hypersensitivity disorders are inappropriate or exaggerated immune reactions to foreign antigens. Mast cell stabilizersĬlinicians who give any of these immunomodulators should be prepared to identify and treat anaphylaxis Anaphylaxis Anaphylaxis is an acute, potentially life-threatening, IgE-mediated allergic reaction that occurs in previously sensitized people when they are reexposed to the sensitizing antigen. read more may be reactivated by systemic corticosteroid use. Tuberculosis most commonly affects the lungs. ![]() Latent tuberculosis Tuberculosis (TB) Tuberculosis is a chronic, progressive mycobacterial infection, often with an asymptomatic latent period following initial infection. Most children treated with inhaled corticosteroids eventually reach their predicted adult height. Whether inhaled corticosteroids suppress growth in children is unclear. #Medicine that treatment nocturnal asthma skin#read more, skin atrophy, hyperphagia, and easy bruisability. Diagnosis is by ophthalmoscopy and slit-lamp examination. The main symptom is gradual, painless vision blurring. read more, cataracts Cataract A cataract is a congenital or degenerative opacity of the lens. ![]() They include suppression of the adrenal-pituitary axis, osteoporosis Osteoporosis Osteoporosis is a progressive metabolic bone disease that decreases bone mineral density (bone mass per unit volume), with deterioration of bone structure. Systemic effects are all dose related, can occur with oral or inhaled forms, and when due to inhaled forms, occur mainly with doses > 800 mcg/day. Adverse local effects of inhaled corticosteroids include dysphonia and oral candidiasis, which can be prevented or minimized by having the patient use a spacer, gargle with water after corticosteroid inhalation, or both. They substantially reduce the need for maintenance oral corticosteroid therapy. ![]() Inhaled corticosteroids have no role in acute exacerbations but are indicated for long-term suppression, control, and reversal of inflammation and symptoms. Daily use or diminishing effects of short-acting beta agonists or use of ≥ 1 canister per month suggests inadequate control and the need to begin or intensify other therapies. Because the safety and efficacy of long-acting beta agonists have been demonstrated only when used in combination with an inhaled corticosteroid, all long-acting and ultra-long beta agonists should be used only in combination with an inhaled corticosteroid for patients whose condition is not adequately controlled with other asthma controllers (eg, low- to medium-dose inhaled corticosteroids) or whose disease severity clearly warrants additional maintenance therapies. The safety of regular long-term use of beta agonists has been confirmed by multiple randomized, controlled trials and meta-analyses, including a large international safety study that was followed by removal of a black box warning by the Food and Drug Administration ( 1 Treatment reference Major drug classes commonly used in the treatment of asthma and asthma exacerbations include Bronchodilators (beta-2 agonists, anticholinergics) Corticosteroids Leukotriene modifiers Mast cell. ![]()
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